Glycoinformatics and Systems Glycobiology II

发布者:吕晓燕发布时间:2018-07-06浏览次数:19



In the morning of June 22, three professors made wonderful presentations at the Triumphant Hall of the Seaview Garden Hotel. Prof. Xinshan Ye and Prof. Kan Ding chaired the session of "Glycoinformatics and Systems Glycobiology II". The overview of this session is as follows:


Prof. Hui Zhang

The topic of professor Hui Zhang (Johns Hopkins University, USA)’talk is "multi-omic analysis of tumor tissues reveals a large number of glycopeptides and their association with glycosylation enzymes". They bridged the gaps among alterations in gene and protein expression, protein glycosylation, and phosphorylation by providing the most complete landscape of glycoproteome in related to proteome and genome. They demonstrated the possibility of classifying the pathological outcome of cancer from normal tissues of HGSOC using glycans on the glycoproteins from tissues.


Prof. Xing Chen

Professor Xing Chen (Peking University, China) introduced a liposome-assisted strategy for specific labeling of glycosylation in vivo. The LABOR strategy exploits ligand-targeted liposomes to deliver sialic acid analogs. The azido sialic acids are metabolically incorporated into cellular sialoglycans and subsequently conjugated with imaging probes or affinity tags via click chemistry. This approach has enabled fluorescent imaging and glycoproteomic analysis of tumor-associated sialoglycans and brain sialylation in mice.


Prof. Tao Jiang

Professor Tao Jiang (Ocean University of China, China) made a presentation about chemical modification of marine polysacchride. In their work, based on a mannose-binding protein (MBP) receptor-binding strategy, the mannose groups were conjugated to polysacchride via an amide linker. They evaluated the binding and internalization of the final product and assessed changes in the morphology and function of macrophages. Based on their results, they synthesized a series of macromolecular magnetic resonance imaging agents, which had great application prospect in lymphatic system development and disease detection.