Glycoinformatics and Systems Glycobiology I


On 21thJune afternoon,five reporters made wonderful presentationsat the Sea Joy Hall of the Seaview Garden Hotel. Prof. Jianning Zhang and Prof. Jian Liu chaired the session of "Glycoinformatics and Systems Glycobiology I". The overview of this session is as follows:

Prof. Iain Wilson

The topic of ProfessorIain Wilson (University of Natural Resources and Life Sciences, Austria)’s presentation was ‘the expanding glycouniverse: diverse glycan modifications in lower eukaryotes’. Their studies demonstrated a wide range of new glycan structures in many lower eukaryotes by using a mix of approaches, including off-line LC-MS analyses This works indicated that each species has specific glycome and a set of specific glycosyltransferases.

Prof. Lianchun Wang

Professor Lianchun Wang (University of Georgia, USA)introduced a mutant cell library for systematic analysis of heparan sulfate. This mutant cell library harbors all the potential HS structure alterations in the cell.It represents a novel test platform that enables robust and systematic interrogation of the roles and related structure of HS in a cellular context with direct implication in vivo.

Prof. Kisung Ko

Professor Kisung Ko (Chung-Ang University, Korea) reported expression and glycolmodification of immunotherapeutic proteins in plant. They aimed to develop a plant system to express a large amount of recombinant therapeutic proteins in plant cells. And currently, they have successfully developed plant expression systems for production of recombinant vaccines and monoclonal antibodies for immunotherapy.

Prof. Katharina Paschinger

Professor Katharina Paschinger (University of Natural Resources and Life Sciences,, Austria)’s talk was themed around unexpected N-glycomic complexity in insects. Their data not only showed that the concept of ‘simple’ organisms possessing only ‘simple’ glycans is not a true reflection of the actually complex biosynthetic glycosylation capacity of insects, but have repercussions for the use of insect cell lines for recombinant protein expression.

Dr. Yue Wang

Doctor Yue Wang (Peking University, China) made a presentation about discovery of cell-permeable O-GlcNActransferase inhibitors via tethering in situ click chemistry. He and his co-workers found two cell-permeable OGT inhibitors (APNT and APBT) via “tethering in situ click chemistry (TISCC)”. They suggested that TISCC can be utilized to discover novel lead compounds from components which exhibited very weak binding to the target.