Glycans in Neuroscience, Cell Recognition, Immunity and Microbiology I

发布者:吕晓燕发布时间:2018-07-05浏览次数:11


On 21th June morning, Prof. Jianguo Gu and Prof. Michael Demetriou chaired the session of "Glycans in Neuroscience, Cell Recognition, Immunity and Microbiology I". Prof. Michael Pierce, Prof. Xiaolian Zhang, Prof. Fei Liu, Prof. Juzheng Sheng and Prof. Jinyou Duan made wonderful presentations at the Triumphant Hall of the Seaview Garden Hotel. The overview of this session is as follows:

Prof. Michael Pierce

Prof. Michael Pierce (University of Georgia, USA) introduced the comparative microbial glycan binding specificites of three intelectins (XCGL-1, hIntL-1, hIntL-2). He and his co-workers demonstrated that the glycan binding specificities of the two human intelectins (hIntL-1 and -2) were dependent on at least two amino acids and illustrated their specialized functions as microbial recognition molecules.

Prof. Xiaolian Zhang

Prof. Xiaolian Zhang (Wuhan University, China) made a presentation about ManLAM, a major lipoglycan of Mycobacterium tuberculosis immunosuppressive epitope. Xiaolian Zhang’s group clarified the immune regulation mechanism of ManLAM. ManLAM-MR/CD44/TLR2 may serve as therapeutic targets for TB treatment.

Prof. Fei Liu

The third speaker was Prof. Fei Liu ((New York State Institute for Basic Research in Developmental Disabilities, USA). In her group’s study, impaired brain glucose up-take and metabolism contribute to AD pathogenesis via reduction of protein O-GlcNAcylation by (1) causing abnormal hyperphosphorylation of tau and tau neurofibrillary degeneration, and (2) leading to a down-regulation of PKA-CREB signaling and deficit in learning and memory.

Prof. Juzheng Sheng

In Prof. Juzheng Sheng’s (Shandong University, China) talk, three novel chondroitin synthase (ApCS, AuCS and McCS ) from bacteria were identified and characterized. They found that the up-regulated extent caused by the binding of the donor was one possibly essential factor in successful polymerization reaction, which enhanced the understanding of the mode of action of glycosyltransferase.

Prof. Jinyou Duan

Prof. Jinyou Duan (Northwest A&F University, China) demonstrated that covalent-coupling glycan to streptomycin oramikacin significantly improved intracellular bactericidal capacity towards multiple organisms within phagocytic or nonphagocytic cells. Furthermore, glyco-conjugate remarkably reduced mortality of infected TLR2 deficient mice. These findings might open up a new avenue to combat intracellular bacterial infection by aminoglycosides antibiotics at a lower effective dose.